The ACT protocol: Assess, Confirm, Treat

The ACT protocol is designed to offer you and your patients a clear understanding of the Carticel treatment process. From a patient’s first visit, through biopsy, surgery and rehabilitation, the Carticel journey should be viewed as a single ACT.


  • Thorough knee exam, including review of medical history, symptoms, previous surgical intervention, and patient expectations
  • Imaging as needed, including X-rays, MRI, CT Scans, etc.
  • Consider any comorbidities that may need to be addressed prior to or concurrent with treatment
  • If cartilage injury is suspected, counsel patient on treatment options appropriate given the severity of their condition
  • Advise patient on the benefits and risks of treatment with Carticel; reference Patient Education Brochure and other educational resources
  • Set expectations of protected weight-bearing for the first 6 to 8 weeks following surgery


  • Confirm patient’s initial commitment to Carticel treatment plan
  • Ensure patient understands that the appropriate treatment for their condition can only be confirmed via arthroscopy
  • Contact your Carticel Cell Therapy Specialist to discuss patient candidacy and to request Cartilage Biopsy Transport Kit
  • Schedule arthroscopy
  • Conduct thorough diagnostic arthroscopy to confirm Carticel candidacy


  • If Carticel candidacy is confirmed, harvest biopsy in accordance with standard protocols
  • Schedule implantation surgery when mutually convenient, but not earlier than 6 weeks from date of biopsy
  • Perform Carticel implantation surgery in accordance with standard protocols
  • Prescribe personalized rehabilitation physical therapy regimen, referencing Carticel Rehabilitation Guidelines provided by your Carticel Cell Therapy Specialist
  • Monitor patient’s progress throughout rehabilitation period